CovidV1, Main, Exploration, bibRecord, 000A87

OT-1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal Chlamydia muridarum Infection

Identifieur interne : 000A87 ( Main/Exploration ); précédent : 000A86; suivant : 000A88

OT-1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal Chlamydia muridarum Infection

Auteurs : Srikanth Manam [États-Unis] ; Bruce J. Nicholson [États-Unis] ; Ashlesh K. Murthy [États-Unis]

Source :

Pathogens and disease [ 2049-632X ] ; 2013.

RBID : PMC:3641702

Abstract

Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide and leads to serious pathological sequelae in the upper genital tract (UGT) including pelvic inflammatory disease, ectopic pregnancy, and infertility. Several components of the host immune responses have been shown to contribute to the UGT pathology following genital chlamydial infection. We have shown recently that CD8⁺ T cells induce the chlamydial UGT pathology via the production of TNF-α. However, those studies did not determine whether the pathology is mediated by bystander or antigen-specific CD8⁺ T cells. In this study, we compared chlamydial clearance and UGT pathology in OT-1 transgenic mice and the corresponding C57BL/6J wild type mice following primary intravaginal C. muridarum infection. All CD8⁺ T cells in the OT-1 mice respond only to the Ova 257–264 peptide and are incapable of responding to other antigenic epitopes including those of Chlamydia. OT-1 mice displayed vaginal chlamydial clearance comparable to the wild type animals. However, both oviduct and uterine horn pathology were minimal in the OT-1 mice compared to the high degree of pathology observed in the wild type animals. These results strongly suggest that Chlamydia-specific, not bystander, CD8⁺ T cells mediate the UGT pathological sequelae following genital chlamydial infection.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641702

DOI: 10.1111/2049-632X.12032
PubMed: 23620186
PubMed Central: 3641702

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">OT-1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal <italic>Chlamydia muridarum</italic>
 Infection</title>
<author><name sortKey="Manam, Srikanth" sort="Manam, Srikanth" uniqKey="Manam S" first="Srikanth" last="Manam">Srikanth Manam</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, Midwestern University, Downers Grove, IL 60515</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Pathology, Midwestern University, Downers Grove</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Bruce J" sort="Nicholson, Bruce J" uniqKey="Nicholson B" first="Bruce J." last="Nicholson">Bruce J. Nicholson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78212</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Murthy, Ashlesh K" sort="Murthy, Ashlesh K" uniqKey="Murthy A" first="Ashlesh K." last="Murthy">Ashlesh K. Murthy</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, Midwestern University, Downers Grove, IL 60515</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Pathology, Midwestern University, Downers Grove</wicri:cityArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23620186</idno>
<idno type="pmc">3641702</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641702</idno>
<idno type="RBID">PMC:3641702</idno>
<idno type="doi">10.1111/2049-632X.12032</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000510</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000510</idno>
<idno type="wicri:Area/Pmc/Curation">000510</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000510</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000451</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000451</idno>
<idno type="wicri:Area/Ncbi/Merge">000326</idno>
<idno type="wicri:Area/Ncbi/Curation">000326</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000326</idno>
<idno type="wicri:Area/Main/Merge">000A89</idno>
<idno type="wicri:Area/Main/Curation">000A87</idno>
<idno type="wicri:Area/Main/Exploration">000A87</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">OT-1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal <italic>Chlamydia muridarum</italic>
 Infection</title>
<author><name sortKey="Manam, Srikanth" sort="Manam, Srikanth" uniqKey="Manam S" first="Srikanth" last="Manam">Srikanth Manam</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, Midwestern University, Downers Grove, IL 60515</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Pathology, Midwestern University, Downers Grove</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Nicholson, Bruce J" sort="Nicholson, Bruce J" uniqKey="Nicholson B" first="Bruce J." last="Nicholson">Bruce J. Nicholson</name>
<affiliation wicri:level="2"><nlm:aff id="A2">Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78212</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Texas</region>
</placeName>
<wicri:cityArea>Department of Biochemistry, The University of Texas Health Science Center at San Antonio, San Antonio</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Murthy, Ashlesh K" sort="Murthy, Ashlesh K" uniqKey="Murthy A" first="Ashlesh K." last="Murthy">Ashlesh K. Murthy</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Department of Pathology, Midwestern University, Downers Grove, IL 60515</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Department of Pathology, Midwestern University, Downers Grove</wicri:cityArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Pathogens and disease</title>
<idno type="eISSN">2049-632X</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1"><italic>Chlamydia trachomatis</italic>
 is the most common bacterial sexually transmitted disease worldwide and leads to serious pathological sequelae in the upper genital tract (UGT) including pelvic inflammatory disease, ectopic pregnancy, and infertility. Several components of the host immune responses have been shown to contribute to the UGT pathology following genital chlamydial infection. We have shown recently that CD8<sup>+</sup>
 T cells induce the chlamydial UGT pathology via the production of TNF-α. However, those studies did not determine whether the pathology is mediated by bystander or antigen-specific CD8<sup>+</sup>
 T cells. In this study, we compared chlamydial clearance and UGT pathology in OT-1 transgenic mice and the corresponding C57BL/6J wild type mice following primary intravaginal <italic>C. muridarum</italic>
 infection. All CD8<sup>+</sup>
 T cells in the OT-1 mice respond only to the Ova 257–264 peptide and are incapable of responding to other antigenic epitopes including those of <italic>Chlamydia</italic>
. OT-1 mice displayed vaginal chlamydial clearance comparable to the wild type animals. However, both oviduct and uterine horn pathology were minimal in the OT-1 mice compared to the high degree of pathology observed in the wild type animals. These results strongly suggest that <italic>Chlamydia</italic>
-specific, not bystander, CD8<sup>+</sup>
 T cells mediate the UGT pathological sequelae following genital chlamydial infection.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Texas</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Illinois"><name sortKey="Manam, Srikanth" sort="Manam, Srikanth" uniqKey="Manam S" first="Srikanth" last="Manam">Srikanth Manam</name>
</region>
<name sortKey="Murthy, Ashlesh K" sort="Murthy, Ashlesh K" uniqKey="Murthy A" first="Ashlesh K." last="Murthy">Ashlesh K. Murthy</name>
<name sortKey="Nicholson, Bruce J" sort="Nicholson, Bruce J" uniqKey="Nicholson B" first="Bruce J." last="Nicholson">Bruce J. Nicholson</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A87 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000A87 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    CovidV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:3641702
   |texte=   OT-1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal Chlamydia muridarum Infection
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:23620186" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a CovidV1

This area was generated with Dilib version V0.6.33.
Data generation: Fri Mar 27 18:14:15 2020. Site generation: Sun Jan 31 15:15:08 2021

Serveur d'exploration Covid

OT-1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal Chlamydia muridarum Infection

OT-1 Mice Display Minimal Upper Genital Tract Pathology Following Primary Intravaginal Chlamydia muridarum Infection

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration Covid
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.